Glyburide Is Anti-inflammatory and Associated with Reduced Mortality in Melioidosis
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منابع مشابه
Glyburide Is Anti-inflammatory and Associated with Reduced Mortality in Melioidosis
BACKGROUND Patients with diabetes mellitus are more prone to bacterial sepsis, but there are conflicting data on whether outcomes are worse in diabetics after presentation with sepsis. Glyburide is an oral hypoglycemic agent used to treat diabetes mellitus. This K(ATP)-channel blocker and broad-spectrum ATP-binding cassette (ABC) transporter inhibitor has broad-ranging effects on the immune sys...
متن کاملA high anti-inflammatory response is associated with intermediate-term mortality in patients with sepsis
Methods We included consecutive patients admitted with severe sepsis or septic shock to the Intensive Care Units (ICU) of 2 tertiary care centres in The Netherlands between January 2011 and July 2013 with a length of stay of at least 4 days. We excluded patients with prior immune deficiency. The anti-inflammatory response was assessed through interleukin (IL)-10 plasma concentrations on admissi...
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BACKGROUND Burkholderia pseudomallei infection (melioidosis) is an important cause of community-acquired Gram-negative sepsis in Northeast Thailand, where it is associated with a ~40% mortality rate despite antimicrobial chemotherapy. We showed in a previous cohort study that patients taking glyburide ( = glibenclamide) prior to admission have lower mortality and attenuated inflammatory respons...
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Patients with chronic obstructive pulmonary disease (COPD) have an increased risk of ischaemic heart disease (IHD). Statins reduce mortality and morbidity in IHD. It has been hypothesised that statin treatment is associated with reduced long-term mortality in patients with COPD. Using a retrospective cohort design, 854 consecutive patients (mean age 70.8 yrs; 51.5% female) with a diagnosis of C...
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BACKGROUND Brain edema is a serious complication of ischemic stroke that can lead to secondary neurological deterioration and death. Glyburide is reported to prevent brain swelling in preclinical rodent models of ischemic stroke through inhibition of a non-selective channel composed of sulfonylurea receptor 1 and transient receptor potential cation channel subfamily M member 4. However, the rel...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2011
ISSN: 1058-4838,1537-6591
DOI: 10.1093/cid/ciq192